Lokomotion started trans-alp rail operation back in 2001. It is a joint-venture of DB Schenker Rail Deutschland AG (30%), RTC - Rail Traction Company SpA (30%), STR-Brenner Schienentransport AG (20%) and Kombiverkehr GmbH & Co KG (20%). In Italy Lokomotion operates under the license of RTC.

Per 01.12.2006, Lokomotion added five ES64 F4 series locomotives to its fleet, acquired from MRCE Dispolok, that before leased these engines to Lokomotion and its partner RTC. The five units, ES 64 F4-007, 012, 014, 017 and 018 initially kept their yellow and silver base livery.

On 24.11.2010, unit ES 64 F4-017 was seen in Kassel, where it was pushed inside the paint shops of Bombardier's (!) assembly factory. Around two weeks later the engine re-appeared, in the Lokomotion 'Zebra'-livery.

Siemens 20727 2004 ES 64 F4 Bo'Bo'-el 189 907     Siemens 20983 2005 ES 64 F4 Bo'Bo'-el ES 64 F4-012     Siemens 20988 2005 ES 64 F4 Bo'Bo'-el 189 914     Siemens 21060 2005 ES 64 F4 Bo'Bo'-el 189 917     Siemens 21062 2005 ES 64 F4 Bo'Bo'-el 189 918